Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1583 | 1583-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, V82A, L90LM | L10F, G73C | I15V, L19I, K20R, M36I, R41K, I62V, L63P, A71V, I72V, P79Q, I93L |
| >1583-30710| codons 4-99 TLWQRPFVTIKVGGQIREALLDTGADDTILEEINLPGKWKPKIIGGIGGFIKVRQYDQVP IEICGHKVVCTVLVGQTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, L210SW, T215Y | T39A, K43E, V60VI, R83K, V118I, I178L, I202V, H208HY, R211RK, L228R |
| >1583-30710| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKDSTKWRKIVDFRELNKKTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVIYQYMDDLYVGSDLEIGQHRTKVEELRQYLWKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |