<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2239 2239-30723 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y   K101E, Y181C, G190A A98G, V108I, E138EK K43Q, E44D, K64R, S68R, V118I, K122E, I135T, G196E, T200I, I202IM, E203K, Q207E, H208F, R211K, K223EQ P217PS
>2239-30723| codons 38-247
CTELEQDGKISKIGPENPYNTPVFAIRKKNRTKWRKVVDFRELNKRTQDFWEVQLGIPHP
GGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIEQHRIKMKELREFLWKWGFYTS
DKKHQQEPPFLWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S, L90M   Q7D, L10I, I15V, G16E, L19T, K20L, E35D, M36I, N37E, I62V, L63H, K70E, A71V, I72V, T74S, I93L  
>2239-30723| codons 4-99
TLWDRPIVTIKVEGQTLEALLDTGADDTVLEDIELPGRWKPKMIVGIGGFVKVRQYDQVH
IEICGHEVVGSVLVGPTPSNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006