Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2239 | 2239-30723 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | Q7D, L10I, I15V, G16E, L19T, K20L, E35D, M36I, N37E, I62V, L63H, K70E, A71V, I72V, T74S, I93L |
| >2239-30723| codons 4-99 TLWDRPIVTIKVEGQTLEALLDTGADDTVLEDIELPGRWKPKMIVGIGGFVKVRQYDQVH IEICGHEVVGSVLVGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K101E, Y181C, G190A | A98G, V108I, E138EK | K43Q, E44D, K64R, S68R, V118I, K122E, I135T, G196E, T200I, I202IM, E203K, Q207E, H208F, R211K, K223EQ | P217PS |
| >2239-30723| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIRKKNRTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIEQHRIKMKELREFLWKWGFYTS DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |