Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2238 | 2238-30721 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A | L24I, L33F | L10V, K20R, E35D, M36I, N37D, R57RK, Q61QDEH, I62V, L63E, I64V, T74S |
| >2238-30721| codons 4-99 TLWQRPVVTIKIGGQLREALIDTGADDTVFEDIDLPGRWKPKLIGGIGGFAKVKQYDHVE VEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219KN | E44D, V60I, V118I, K122E, D123NS, I135V, G196E, T200A, E203V, Q207E, H208Y, R211K, H221HY, L228LH |
| >2238-30721| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIVELREYLWKWGFYTP DNKYQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |