Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2237 | 2237-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82F, L90M | L23I, L33F, K43T | L10I, I13V, E35D, M36I, N37NS, I62V, L63P, I64V, A71AV, I93L |
| >2237-30715| codons 4-99 TLWQRPIVTVKIGGQLKEAILDTGADDTVFEDISLPGRWTPKIIGGIGGFVKVRQYDQVP VEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75T, M184V, L210W, T215Y | K219E | L100I, K103N | T69N, K122E, I135M, T200A, I202IV, E203D, L228H |
| >2237-30715| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSNKWRKVTDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKVDELRQHLWRWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |