Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2088 | 2088-30709 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | I13M, I15V, Q18QH, K20I, E35D, M36I, N37PS, K55KR, I62V, L63P, I64V, I66V, K70KE |
| >2088-30709| codons 4-99 TLWQRPFVTMKVGGHLIEALLDTGADDTVLEDISLPGRWKPKIIGGIGGFVRVRQYDQVP VEVCGHEAITTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K103N | K43Q, K49R, V60I, V118I, K122E, D123N, S162D, K166R, G196E |
| >2088-30709| codons 38-247 CTELEQEGKISRIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |