Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2086 | 2086-30624 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C | T39A, K43E, E44D, V60I, K101Q, V118I, K122E, I135M, V179VI, V245E |
| >2086-30624| codons 38-247 CAELEEDGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L10I, T12P, I13V, K14R, D60E, I62V, L63P, A71T, I72V, P79S, V82I, Q92R, I93L |
| >2086-30624| codons 4-99 TLWQRPIVPVRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYEQVP IEICGHKTVGTVLVGSTPINVIGRNLLTRLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |