Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2083 | 2083-30609 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | G73S | L10I, T12E, I13V, K20I, M36I, K55R, I62V, L63P, C67F, A71V, I72M |
| >2083-30609| codons 4-99 TLWQRPIVEVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVRQYDQVP IEIFGHKVMSTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219N | K101E, Y181V | T39A, E40V, K43E, V118I, K122P, S162C, S163G, I178IM, V179I, R211K, D218E |
| >2083-30609| codons 38-247 CAVLEEEGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSIPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCGMTKILEPFRKQNPDMIIVQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |