Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2085 | 2085-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, I84V, L90M | V11I, L33F, F53L, G73T | L10I, I13V, I62V, L63P, A71V, I72V |
| >2085-30610| codons 4-99 TLWQRPIITVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGLLKVRQYDQVP IEICGHKVVTTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74LI, M184V, L210W, T215F | K219Q | E40F, K43N, K122E, D123DN, S162SN, K166R, G196E, H208Y, R211RK, D218E, L228H, V245M |
| >2085-30610| codons 38-247 CTFLENEGKISKIGPENPYNTPVFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |