Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2010 | 2010-30606 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, V82A, L90M | V11I, L33F, M46V, F53L | L10I, I13V, L19I, K20R, E35D, M36I, N37D, K55R, R57K, L63P, A71V |
| >2010-30606| codons 4-99 TLWQRPIITVKIGGQIREALLDTGADDTVFEDIDLPGRWKPKVIGGVGGLIRVKQYDQIP IEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74LV, Y115YF, M184MV, T215F | K219Q | Y181YC | T39E, K49R, V60I, V90I, A98S, K122E, D123E, P170PS, D218E, L228LH, I244IV | S162DE |
| >2010-30606| codons 38-247 CEELEKEGKISRIGPENPYNTPIFAIKKKNSTRWRKVVDFRELNKRTQDFWEIQLGIPHP SGLKKKKSVTVLDVGDAFFSVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQESMTKILESFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPVVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |