Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1963 | 1963-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69A_EG, L210W, T215Y | A62V | Y181C, G190S | K101H | T39A, E44ED, K49R, E53D, K64R, V118VI, K122E, I135T, Q207E, R211K, L228H |
| >1963-30528| codons 38-247 CAEMEKDGKISRIGPDNPYNTPVFVIRKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVSSDLEIGQHRTKIEELREHLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | V11VI, L33F, K43T | L10V, T12P, I13V, K14GR, K20KR, E35ED, M36L, N37D, K55R, R57K, L63P, H69R, A71T, I93L, C95F |
| >1963-30528| codons 4-99 TLWQRPVIPVRIGGQLREALLDTGADDTVFEDLDLPGRWTPKIIGGIGGFVRVKQYDQIP IEICGRKTIGTVLVGPTPANVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |