<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1963 1963-30528 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V, L90M V11VI, L33F, K43T L10V, T12P, I13V, K14GR, K20KR, E35ED, M36L, N37D, K55R, R57K, L63P, H69R, A71T, I93L, C95F  
>1963-30528| codons 4-99
TLWQRPVIPVRIGGQLREALLDTGADDTVFEDLDLPGRWTPKIIGGIGGFVRVKQYDQIP
IEICGRKTIGTVLVGPTPANVIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69A_EG, L210W, T215Y A62V Y181C, G190S K101H T39A, E44ED, K49R, E53D, K64R, V118VI, K122E, I135T, Q207E, R211K, L228H  
>1963-30528| codons 38-247
CAEMEKDGKISRIGPDNPYNTPVFVIRKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVSSDLEIGQHRTKIEELREHLWKWGFYTP
DKKHQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006