Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1962 | 1962-30523 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | T39K, K43E, E44A, K64R, V118I, K122E, I142V, D177N, T200A, H208Y, R211K, D218E, F227Y, L228H |
| >1962-30523| codons 38-247 CKELEEAGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTP ENKHQKEPPYHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, L33F, K43T, G73T | E34Q, N37S, R41K, D60DE, I62V, L63P, I66V, C67F, A71T, I72T, V77I, I93L |
| >1962-30523| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTVFQEMSLPGKWTPKIIGGIGGFMKVRQYEQVP IEVFGHKTTTTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |