Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1961 | 1961-30521 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84C, L90M | L10F, L89V | I13V, G16E, Q18QH, K20I, M36I, I62V, L63H, A71T, C95F |
| >1961-30521| codons 4-99 TLWQRPFVTVKIEGHLIEALLDTGADDTVLEEINLPGRWKPKLIGGIGGFIKVRQYDQVH IEICGHKTIGTVLVGPTPVNCIGRNVMTQIGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W | T215C, K219N | K103H, Y181C, G190A | K101N | E44ED, K102Q, V118I, K122E, I135V, H208Y, R211K, F214FL |
| >1961-30521| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLNQHKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGLCTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |