Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1017 | 1017-30507 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, G73S | L10I, I15V, K20I, N37C, R41K, K45KR, I62V, L63P, C67F, H69HQ, A71I, I72K, P79PA, I85IV, I93L |
| >1017-30507| codons 4-99 TLWQRPIITIKVGGQLIEALLDTGADDTVLEEMCLPGKWKPRIIGGIGGFVKVRQYDQVP IEIFGQKIKSTVLVGATPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219R | Y188YH | T39TA, E44D, V118I, K122E, I178IM, T200TA, E203K, Q207E, H208Y, R211K, K223E, E224EK |
| >1017-30507| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYIDDLHVGSDLEIGQHRAKIKELREYLWKWGFYTP DRKHQEKPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |