Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1016 | 1016-30428 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48M, I54S, V82A, L90LM | L33F | L10I, G16A, L19LV, E34Q, N37D, Q61K, I62V, L63P, A71I, T74S, V77I, I93L | Q92S |
| >1016-30428| codons 4-99 TLWQRPIVTIKIAGQVKEALLDTGADDTVFQEMDLPGRWKPKLIMGIGGFSKVRQYDKVP IEICGHKIIGSVLIGPTPANIIGRNLMTSLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75T, M184V, L210W, T215Y | K219R | L100I, K103N | T39A, E44D, E79ED, R83K, V118I, K122E, S162D, V179T, V189VI, Q207E, R211K, D218E |
| >1016-30428| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVTDFRDLNKKTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDITIYQYVDDLYIGSDLEIGQHRTKIEELREHLWKWGFYTP ERKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |