Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1013 | 1013-30228 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82C, I84V | L10F, L24I, L33F, K43T | I13V, G16A, Y59YF, Q61R, L63P, I64V, K70KR, A71V, I72E, T74S, V77I, P79Q, T91S, I93L |
| >1013-30228| codons 4-99 TLWQRPFVTVKIAGQLKEALIDTGADDTVFEEMNLPGRWTPKLIGGIGGFVKVRQFDRIP VEICGHRVEGSVLIGQTPCNVIGRNLLSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74LI, M184V, L210W | Y181C, G190GA | A98G, V179DY | E40F, K43Q, R83K, K103R, V106VI, L109LIM, I135L, S163SC, I167V, T200A, Q207E, R211K, L228R, D237E, V245E |
| >1013-30228| codons 38-247 CTFLEQEGKISKIGPENPYNTPVFAIKKKDSDKWRKIVDFRELNKKTQDFWEVQLGIPHP GGLKKRKSITVMDVGDAYFSVPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSCMTKVLEPFRKQNPDIYICQYVDDLYVASDLEIGQHRAKIEELREHLWKWGFTTP DKKHQKEPPFRWMGYELHPEKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |