Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2125 | 2125-30812 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210LW, T215Y | A98S, D123E, F171Y, I178IM, Q197E, T200A, R211RK, V245Q |
| >2125-30812| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPYRKQNPDMVIYQYVDDLYVGSDLEIGEHRAKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I84V | L10F, L33F, Q58E, L89LV | I13V, K20R, E35D, M36L, I62V, L63P, V77VI, N83S |
| >2125-30812| codons 4-99 TLWQRPFVTVKIGGQLREALLDTGADDTIFEDLNLPGRWKPKIIGGIGGFIKVREYDQVP IEICGHKAIGTVLIGPTPVSVIGRNVLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |