Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1311 | 1311-30530 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F | I13V, K14R, I15V, K20I, R41K, L63P, I64V, A71V, T74S, P79A, T91S, I93L |
| >1311-30530| codons 4-99 TLWQRPFVTVRVGGQLIEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYDQIP VEICGHKVIGSVLVGATPVNVIGRNLMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | K103N | A98G | T39A, V60I, T69N, D121H, K122E, I135L, S162D, V179I, R211K, D218E |
| >1311-30530| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |