Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1310 | 1310-30516 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54IL, I84V, L90M | L33LF, G73GS, T74TPS | L10I, I13IV, E34EQ, I62IV, L63P, A71AV, I72IMV, V77I, I93L |
| >1310-30516| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFLKVRQYDQVP IEICGHKVVSSVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41LS, L74LV, M184V, L210LW, T215Y | K101KPQT | A98AG, V108VI | K43KQ, S68SG, V118VI, K122KE, T165TI, Q174R, Q207DE, H208HY, R211K, L228LH, V245K |
| >1310-30516| codons 38-247 CTESEQEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLTKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKRNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELREYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |