Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1308 | 1308-30408 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A | L24LI, L33F, K43T | L10I, I13V, K20R, E35D, M36I, N37D, I62V, L63Q, I72V, T74S, I85V, L89M |
| >1308-30408| codons 4-99 TLWQRPIVTVKIGGQLREALIDTGADDTVFEDIDLPGRWTPKLIVGIGGFTKVRQYDQVQ IEICGHKAVGSVLVGPTPANIVGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75T, Y115YF, M184V, L210W, T215Y | K219KR | Y188L | Y181YF | K43Q, I94IL, V118I, D123E, K166R, D177E, V189VI, T200A, E203D, Q207E, H208HY, R211K, D218E, L228H, Q242H, V245Q |
| >1308-30408| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKDSTKWRKITDFRELNKRTQDFWEVQLGLPHP AGLKKKKSVTVLDVGDAFFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPEIVIFQYVDDLLIGSDLEIGQHRAKIDELREYLWKWGFYTP ERKHQKEPPFHWMGYELHPDKWTVHPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |