Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1307 | 1307-30331 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I, I54A, I84V, L90M | L10F, L33F, Q58E, N88D, L89V | I13V, L19LI, V56A, L63P, I66F, A71V, V77I |
| >1307-30331| codons 4-99 TLWQRPFVTVKIGGQIKEALLDTGADNTVFEEMNLPGRWKPKIIGGIGGFAKAREYDQIP IEFCGHKVIGTVLIGPTPVNVIGRDVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K43E, E44D, I94L, K102KR, K104KR, V111I, D123E, I135L, D177E, G196E, H208Y, R211K |
| >1307-30331| codons 38-247 CTELEEDGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGLPHP AGLKRKRSVTVLDIGDAYFSVPLDKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |