Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2399 | 2399-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, T215F | K219E | K103KN, Y181C, G190AST | T69N, K101KT, D123E, D177E, G196E, T200A, L228R |
| >2399-30818| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLTKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYMDDLYVTSDLEIEQHRAKIEELRQHLLRWGFFTP DEKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10FY | I15V, G16A, K20V, E34Q, L63Q, I64V, H69Q, T74S, V77I, I85V, L89I, T91S, Q92K |
| >2399-30818| codons 4-99 TLWQRPYVTIKVAGQLVEALLDTGADDTILQEMNLPGRWKPKIVGGIGGFLKVRQYDQIQ VEICGQKAIGSVLIGPTPVNVVGRNIMSKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |