Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2396 | 2396-30804 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215F | K219Q | L100I, K103N | K238T | V60I, K122E, D177E, I178M, V179I, T200A, D218E, E224D | N137NS |
| >2396-30804| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINSETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMIIYQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFFTP EQKHQKDPPFLWMGYELHPDTWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, L76V, I84V, L90M | L10F, G73S, L89V | I13V, I15V, K20I, L33L_L, M36I, I62V, L63P, A71I, I72R, T91S |
| >2396-30804| codons 4-99 TLWQRPFVTVKVGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFLKVRQYDQVP IEICGHKIRSTVVVGPTPVNVIGRNVMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |