Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1012 | 1012-30717 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L10F, L33F, G73S, L89V | I13V, I15V, L19I, K20T, E35D, M36I, R41N, F53Y, K55N, D60E, L63P, I64L, I66F, H69K, A71V, V77I, Q92K, T96S |
| >1012-30717| codons 4-99 TLWQRPFVTVKVGGQITEALLDTGADDTIFEDINLPGNWKPKIVGGIGGYMNVRQYEQIP LEFCGKKVISTVLIGPTPVNVIGRNVMTKIGCSLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74IV, M184V, L210W, T215Y | K219E | Y181C, Y188L | K43E, E44A, K101Q, K102KR, V118I, K122Q, D177E, V179I, V189I, G196E, R211K |
| >1012-30717| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQRKKSVTVLDVGDAYFSIPLDQDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIIICQYVDDLLIGSDLEIEQHRTKIEELRQHLWKWGFYTP DEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |