Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1011 | 1011-30624 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84V, L90M | L10LF, G73T | I13IM, K20I, L63P, I64V, K70R, A71V, I85IV | P79ADNT |
| >1011-30624| codons 4-99 TLWQRPFVTMKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVRQYDQIP VEICGHRVITTVLVGTTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184MV, L210L*W, T215Y | K103KN | K43KE, K122E, I135IT, S162C, T200A, Q207E, R211K |
| >1011-30624| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |