Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1305 | 1305-30717 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47IV, I54V, V82VA | L33LF | L10I, K14R, K20KT, R41K, L63P, A71AV, I72V |
| >1305-30717| codons 4-99 TLWQRPIVTIRIGGQLTEALLDTGADDTIFEEMNLPGKWKPKIVGGIGGFVKVRQYDQIP IEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, L210W, T215Y | D67G, K219N | L100LI, K103N | K43E, E44EAD, S68G, K102R, V118VI, K122KE, D123E, I135T, S162SN, D177E, G196E, Q197K, E203A, R211RK |
| >1305-30717| codons 38-247 CTELEEDGKISKIGPENPYNTPVFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEKHRTKIAELRQHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |