Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1303 | 1303-30711 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | Y188L | A98G | K43Q, V60I, T69N, V106I, L109LIM, D123E, I135V, S162SDGN, Q174H, D177E, V179VI, G196E, H208Y, R211K, W212WC, D218E, V245E |
| >1303-30711| codons 38-247 CTELEQEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSITVMDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKHNPEIIIYQYVDDLLVGSDLEIEQHRTKIEELRQYLLKCGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GV, I54M, V82A, L90M | L10I, R41K, I62V, L63P, A71T, T74S, V77I, I93L |
| >1303-30711| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIVGIGGFMKVRQYDQVP IEICGHKTIGSVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |