Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2294 | 2294-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | V108I, F227L | K43Q, E44D, K49R, A98S, V111I, D123E, I135V, S162A, T165I, D177E, I178IL, I195IK, G196GE, T200A, Q207DE, H208Y, R211K, K223E, L228H, Q242H | E203EKMV |
| >2294-30724| codons 38-247 CTELEQDGKISRIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTILDIGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQASMIKILEPFRKQNPELVIYQYVDDLYVGSDLEKEQHRAKIVELREYLWKWGFYTP DRKHQEEPPLHWMGYELHPDKWTVHPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48L, I54V, V82S | L24I, F53L, Q58E | L10IV, N37S, D60E, I62V, L63P, A71V, T74S, V77I, I93L |
| >2294-30724| codons 4-99 TLWQRPVVTIKIGGQLKEALIDTGADDTVLEEMSLPGRWKPKMILGIGGLVKVREYEQVP IEICGHKVIGSVLIGPTPSNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |