<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2294 2294-30724 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48L, I54V, V82S L24I, F53L, Q58E L10IV, N37S, D60E, I62V, L63P, A71V, T74S, V77I, I93L  
>2294-30724| codons 4-99
TLWQRPVVTIKIGGQLKEALIDTGADDTVLEEMSLPGRWKPKMILGIGGLVKVREYEQVP
IEICGHKVIGSVLIGPTPSNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y K219R   V108I, F227L K43Q, E44D, K49R, A98S, V111I, D123E, I135V, S162A, T165I, D177E, I178IL, I195IK, G196GE, T200A, Q207DE, H208Y, R211K, K223E, L228H, Q242H E203EKMV
>2294-30724| codons 38-247
CTELEQDGKISRIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
SGLKKKKSVTILDIGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQASMIKILEPFRKQNPELVIYQYVDDLYVGSDLEKEQHRAKIVELREYLWKWGFYTP
DRKHQEEPPLHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006