Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1774 | 1774-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V | V11I, L24I, K43T | L10I, T12P, I13V, K20I, M36I, D60E, L63P, I64V, C67Y, L89I |
| >1774-30708| codons 4-99 TLWQRPIIPVKIGGQLIEALIDTGADDTVLEEINLPGRWTPKMIVGIGGFVKVRQYEQIP VEIYGHKAIGTVLVGPTPANVIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215DY | K219N | Y188L | V118VI, K122E, I135T, T139A, G196E, R211K, I244V, V245E |
| >1774-30708| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNEAPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIEQHRTKIEELRQHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPVELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |