Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1773 | 1773-30605 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, G73S, L89V | L10V, I13V, K14R, I15IV, K20T, I62IV, L63P, I64L, I66F, A71V, I72L |
| >1773-30605| codons 4-99 TLWQRPVVTVRVGGQLTEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFLKVRQYDQVP LEFCGHKVLSTVLVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML | T215C | Y188L | V60VI, V106I, V118VI, K122E, I135V, F214C, H221Y, E224ED, L228HR |
| >1773-30605| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIGQHRTKIEELRQHLLRWGCCTP DKKYQKDPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |