Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1769 | 1769-30430 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54A, V82A, L90M | L33F, K43KT | L10I, E35ED, M36L, N37D, R57RK, I62V, L63P, A71I, I72V, Q92QK, I93L |
| >1769-30430| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEDLDLPGRWTPKMIMGIGGFAKVKQYDQVP IEICGHKIVGTVLVGPTPANIIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | Y181C, G190A | V108I | E44D, V111I, V118I, D123E, D177E, H208Y, R211K, W212C, D218E |
| >1769-30430| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDIGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVASDLEIGQHRTKIEELRQYLWKCGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |