Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1648 | 1648-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, K43T, F53L, T74P | L10I, I13V, K20R, E35D, M36I, N37T, K55R, R57K, I62V, L63P, A71IV |
| >1648-30424| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDITLPGRWTPKIIGGVGGLVRVKQYDQVP IEICGHKVIGPVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M, M184V | A62V, V75I, F77L, F116Y | K103N | S68G, V90VI, K102KR, V118I, K122E, I142T, Q174R, T200TA, F214L | T69V |
| >1648-30424| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGVKWRKLIDLRELNKRTQDFWEIQLGIPHP AGLKRNKSVTVLDVGDAYYSIPLDEDFRKYTAFTIPSINNETPGTRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKRNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |