Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1647 | 1647-30421 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | V11I, L33I, L89V | L10I, I13V, G16A, L19P, K20V, A22V, E35G, N37D, D60E, L63P, K70T, A71I, V77I, I93L | G73E |
| >1647-30421| codons 4-99 TLWQRPIITVKIAGQPVEVLLDTGADDTIIEGMDLPGRWKPKIVGGIGGFMKVRQYEQIP IEICGHTIIETVLIGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W | K219N | L100I, K103N | T39A, K43Q, E44D, V118I, D123E, D177G, V179I, D192H, G196E, T200A, E203V, Q207E, R211N, D218E, L228F, V245E |
| >1647-30421| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGIIIYQYVDDLYVGSHLEIEQHRAKIVELREHLWNWGFTTP ENKHQKEPPFFWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |