<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1646 1646-30403 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M Y181I   T39K, K43E, E44D, K64Y, A98S, K102E, V118I, K122E, K166KR, P170T, V179I, E203K, Q207DE, H208Y, R211K, H221L, K223Q, P243PS  
>1646-30403| codons 38-247
CKELEEDGKISKIGPENPYNTPVFAIYKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
SGLKEKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTRILETFRKQNPDIIIIQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP
DKKLQQEPPFLWMGYELHPDKWTVQSIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, G73T L10I, I13V, L19LV, K20R, L24F, E35D, M36I, K55N, I62V, L63P, A71V, I72K, V77I, I93L  
>1646-30403| codons 4-99
TLWQRPIVTVKIGGQVREALFDTGADDTVFEDINLPGRWKPKIIGGIGGFVNVRQYDQVP
IEICGHKVKTTVLIGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006