Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1646 | 1646-30403 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, G73T | L10I, I13V, L19LV, K20R, L24F, E35D, M36I, K55N, I62V, L63P, A71V, I72K, V77I, I93L |
| >1646-30403| codons 4-99 TLWQRPIVTVKIGGQVREALFDTGADDTVFEDINLPGRWKPKIIGGIGGFVNVRQYDQVP IEICGHKVKTTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | Y181I | T39K, K43E, E44D, K64Y, A98S, K102E, V118I, K122E, K166KR, P170T, V179I, E203K, Q207DE, H208Y, R211K, H221L, K223Q, P243PS |
| >1646-30403| codons 38-247 CKELEEDGKISKIGPENPYNTPVFAIYKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP SGLKEKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILETFRKQNPDIIIIQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP DKKLQQEPPFLWMGYELHPDKWTVQSIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |