Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1643 | 1643-30312 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L33F, L89V | L10I, V11L, I13V, G16A, N37D, K55R, D60E, L63P, H69Y, A71V, I72FL, V77VI, I93L |
| >1643-30312| codons 4-99 TLWQRPILTVKIAGQLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVRVRQYEQIP IEICGYKVLGTVVIGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219R | K103N, Y181C | A98G | K43Q, E44D, V111I, V118I, D123E, I135T, T165I, D177E, I178L, V179I, G196E, T200TA, E203D, H208Y, R211D, H221C, L228H, V245E |
| >1643-30312| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDIGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPELIICQYVDDLYVGSDLEIEQHRAKIDELRQYLWDWGFYTP DRKCQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |