Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1003 | 1003-30303 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219N | K103N, Y181C, G190A | K101H | K43X, E44D, V60I, V118I, K122E, A158T, K166KR, G196E, T200TA, I202V, E203A, H208Y, R211K |
| >1003-30303| codons 38-247 CTELENDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP TIFQSSMTRILEPFRKQNPDIVICQYIDDLYVASDLEIEQHRAKVAELRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F, I84V, L90M | Q58E | L10I, I13V, I15V, K20I, E35D, M36I, N37D, L63P, L89I | D25DH |
| >1003-30303| codons 4-99 TLWQRPIVTVKVGGQLIEALLHTGADDTVLEDIDLPGRWKPKIIGGIGGFIKVREYDQIP IEICGHKAIGTVLVGPTPFNVIGRNIMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |