Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2414 | 2414-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54V, V82CST, L90M | L33F, G73S | L10I, I15V, G16A, K20R, E35D, M36I, N37DE, K55KR, R57K, Q61E, I62V, L63P, A71I, I72IT, I85V, I93L |
| >2414-30821| codons 4-99 TLWQRPIVTIKVAGQLREALLDTGADDTVFEDIELPGRWKPKLIGGIGGFVRVKQYDEVP IEICGHKITSTVLVGPTPTNIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, T215F | K219Q | L100I, K103N | T39A, K122E, Q174QR, D177EG, T200A, Q207E, D218E, L228H, V245K |
| >2414-30821| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPGIVIYQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |