<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1479 1479-30731 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L10F, K43T, L89LV V11L, T12K, I15V, Q18H, L19I, K20V, E21ED, E35D, M36I, N37D, R57K, I62V, L63P, A71I, I85V, Q92K, I93L  
>1479-30731| codons 4-99
TLWQRPFLKIKVGGHIVDALLDTGADDTVLEDIDLPGRWTPKMIGGIGGFVKVKQYDQVP
IEICGHKIIGTVLVGPTPANIVGRNVMTKLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y D67E, K70A K101E, Y181C, G190S A98G T39S, V118I, K122E, S162C, Q174N, V189VI, G196E, T200TA, R211K, L228R, V245VE  
>1479-30731| codons 38-247
CSELEKEGKISKIGPENPYNTPVFAIKKKESTAWRKVVDFRELNKRTQDFWEVQLGIPHP
GGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKNNPDIVICQYMDDLYISSDLEIEQHRAKIEELRQHLWKWGFYTP
DKKHQKEPPFRWMGYELHPDKWTVQPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006