Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1479 | 1479-30731 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F, K43T, L89LV | V11L, T12K, I15V, Q18H, L19I, K20V, E21ED, E35D, M36I, N37D, R57K, I62V, L63P, A71I, I85V, Q92K, I93L |
| >1479-30731| codons 4-99 TLWQRPFLKIKVGGHIVDALLDTGADDTVLEDIDLPGRWTPKMIGGIGGFVKVKQYDQVP IEICGHKIIGTVLVGPTPANIVGRNVMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67E, K70A | K101E, Y181C, G190S | A98G | T39S, V118I, K122E, S162C, Q174N, V189VI, G196E, T200TA, R211K, L228R, V245VE |
| >1479-30731| codons 38-247 CSELEKEGKISKIGPENPYNTPVFAIKKKESTAWRKVVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKNNPDIVICQYMDDLYISSDLEIEQHRAKIEELRQHLWKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |