Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1475 | 1475-30723 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, D30Y, L33F, Q58E, T74P | I13V, I62V, L63P, A71V, V77I, P79D, I93L |
| >1475-30723| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADYTVFEEMNLPGRWKPKIIGGIGGFIKVREYDQVP IEICGHKVIGPVLIGDTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, M184V, T215F | K219Q | L100I, K103N | T39A, K43Q, E44A, V60I, T69H, S117SA, K122E, D123E, S162SDGN, K166R, I167IV, D177DG, V179I, G196E, Q197A, T200E, I202V, E203K, H208Y, R211K, D218E, E224D, L228H, K238R, Q242H | F61FC |
| >1475-30723| codons 38-247 CAELEQAGKISKIGPENPYNTPICAIKKKDSHRWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFAVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTRVLEPFRKQNPGIIIYQYVDDLYVGSDLEIEAHREKVKELRQYLLKWGFFTP EQKHQKDPPFHWMGYELHPDRWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |