Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4021 | 4021-30514 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L10F, G73T | I13V, I15V, K20T, M36I, F53Y, K55N, Q61H, L63P, I64V, A71V |
| >4021-30514| codons 4-99 TLWQRPFVTVKVGGQLTEALLDTGADDTILEEINLPGRWKPKIVGGIGGYLNVRQYDHIP VEICGHKVITTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115YF | T215TI, K219E | K101DE, Y181C, G190A | V108I, V179D | T39TA, S68G, K122E, Q174R, G196K, F214FL, V245K |
| >4021-30514| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKRKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAFFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIDICQYMDDLYVASDLEIKQHRTKIEELRQHLLRWGLITP DEKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |