Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4090 | 4090-40706 | Australia | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 60 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219R | L100I, K103N | E6D, T39AE, E44D, V111I, V118I, K122E, I135T, S163C, K166KR, D177E, G196E, T200A, E203K, Q207E, H208Y, R211K, K223E, D237DE, K277R, L283I, T286A, A288S, I293V, E297Q, I329V, R356K, M357MI, G359S, A371V, I375V, K390R |
| >4090-40706| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSCMTRILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRAKIKELREYLWKWGFYTPDRKHQEEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGAKSLTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKIRSA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, I84V, L90M | V11I, G73S, L89LV | L10IV, T12P, K14R, I15V, K20IT, E35D, M36I, L63P, A71V, I85IV, I93L |
| >4090-40706| codons 1-99 PQITLWQRPVIPIRVGGQLTEALLDTGADDTVLEDINLPGRWKPKIVGGIGGFVKVRQYD QIPIEICGHKVISTVLVGPTPVNVVGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |