<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4090 4090-40706 Australia 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 60

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47IV, I54V, I84V, L90M V11I, G73S, L89LV L10IV, T12P, K14R, I15V, K20IT, E35D, M36I, L63P, A71V, I85IV, I93L  
>4090-40706| codons 1-99
PQITLWQRPVIPIRVGGQLTEALLDTGADDTVLEDINLPGRWKPKIVGGIGGFVKVRQYD
QIPIEICGHKVISTVLVGPTPVNVVGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184MV, L210W, T215Y K219R L100I, K103N   E6D, T39AE, E44D, V111I, V118I, K122E, I135T, S163C, K166KR, D177E, G196E, T200A, E203K, Q207E, H208Y, R211K, K223E, D237DE, K277R, L283I, T286A, A288S, I293V, E297Q, I329V, R356K, M357MI, G359S, A371V, I375V, K390R  
>4090-40706| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSCMTRILEPFRKQNPEIVI
YQYVDDLYVGSDLEIEQHRAKIKELREYLWKWGFYTPDRKHQEEPPFLWMGYELHPEKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGAKSLTEVVPLTQEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKIRSA
HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006