<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4085 4085-40420 Australia 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 59

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y V75A, K219N L100I, K103N   V35M, T39A, E44D, A98S, V118I, K122E, T200M, E203K, Q207E, R211K, V292I, I293V, E312Q, D324E, I329V, G333E, Q334P, G359S, A371V, T377I, K390R  
>4085-40420| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV
FAIKKKDSTKWRKVADFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRMKIKELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE
LELAENREILKQPVHGVYYDPSKELIAEVQKQEPGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIAIESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, I84V   L10I, T12P, E35D, M36I, I62V, L63P, A71V  
>4085-40420| codons 1-99
PQITLWQRPIVPIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFAKVRQYD
QVPIEICGHKVIGTVLVGPTPVNVIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006