Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4085 | 4085-40420 | Australia | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 59 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, I84V | L10I, T12P, E35D, M36I, I62V, L63P, A71V |
| >4085-40420| codons 1-99 PQITLWQRPIVPIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFAKVRQYD QVPIEICGHKVIGTVLVGPTPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | V75A, K219N | L100I, K103N | V35M, T39A, E44D, A98S, V118I, K122E, T200M, E203K, Q207E, R211K, V292I, I293V, E312Q, D324E, I329V, G333E, Q334P, G359S, A371V, T377I, K390R, A400T |
| >4085-40420| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKDSTKWRKVADFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRMKIKELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKQPVHGVYYDPSKELIAEVQKQEPGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIAIESIVIWGKTPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |