Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4085 | 4085-30305 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219N | T39A, E44D, A98S, V118I, K122E, D177DG, T200M, E203K, Q207E, H208Y, R211K, K223E |
| >4085-30305| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIGQHRMKIKELREYLWKWGFYTP DNKHQEEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V | L10I, T12P, E35D, M36I, I62V, L63P, A71V, I72V |
| >4085-30305| codons 4-99 TLWQRPIVPIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKVVGTVVVGPTPVNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |