Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4096 | 4096-30515 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K103KNRS, Y181YC | A98AG, V179E | T39TS, T69TN, D86E, V118VI, A158AS, S162SC, E169ED, T200TA, R211RK, F214L |
| >4096-30515| codons 38-247 CSEMEKEGKISKIGPENPYNTPVFAIKKKDSNRWRKLVDFRELNKRTQEFWEVQLGIPHP GGLKKSKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQCSMTKILDPFRKQNPDIEICQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, E35D, N37D, L63P, A71AITV, I72IV, V77VI, P79PS, I93L |
| >4096-30515| codons 4-99 TLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYDQIP IEICGHKVVGTVLIGSTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |