Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4084 | 4084-30331 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | V11VI | L10Y, I15V, K20I, E21D, E35D, M36I, N37E, K55R, R57K, I62V, L63P, H69HQ, A71T, I72T, I93L, C95F |
| >4084-30331| codons 4-99 TLWQRPYITIKVGGQLIDALLDTGADDTVLEDIELPGRWKPKIIGGIGGFIRVKQYDQVP IEICGQKTTGTVLVGPTPVNVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215F | K219E | K101E, Y181C, G190S | T39A, K49R, T69N, V90I, K122E, D123N, I135L, Q174R, D177E, G196E, R211K, D218E, L228H |
| >4084-30331| codons 38-247 CAELEKEGKISRIGPENPYNTPVFAIKKKNSNRWRKVVDFRELNKRTQDFWEIQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPEIVICQYVDDLYVSSDLEIEQHRTKIEELRQHLLKWGFFTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |